Перегляд за автором "Kavsan, V.M."

Сортувати за: Порядок: Результатів:

  • Characterization of new cell line stably expressing CHI3L1 oncogene 
    Balynska, O.V.; Baklaushev, V.P.; Areshkov, P.O.; Avdieiev, S.S.; Boyko, O.I.; Chekhonin, V.P.; Kavsan, V.M. (Вiopolymers and Cell, 2011)
    Aim. To characterize the immortalized 293 cell line afterstable transfection with human oncogene (CHI3L1). Methods. 293 cells, stably transfected with pcDNA3.1_CHI3L1, and 293 cells, stably transfected with pcDNA3.1 as a ...
  • Chitinase 3-like protein 2 (CHI3L2, YKL-39) activates phosphorylation of extracellular signal-regulated kinases ERK1/ERK2 in human embryonic kidney (hek293) and human glioblastoma (U87 MG) cells 
    Areshkov, P.A.; Kavsan, V.M. (Цитология и генетика, 2010)
    Human cartilage chitinase 3-like protein 2 (CHI3L2, YKL-39) is secreted by articular chondrocytes, also synoviocytes, lung, and heart. Increased levels of YKL-39 have been demonstrated in synovial fluids of patients with ...
  • Comparison of microarray and sage techniques in gene expression analysis of human glioblastoma 
    Kavsan, V.M.; Dmitrenko, V.V.; Shostak, K.O.; Bukreieva, T.V.; Vitak, N.Y.; Simirenko, O.E.; Malisheva, T.A.; Shamayev, M.I.; Rozumenko, V.D.; Zozulyay, Y.A. (Цитология и генетика, 2007)
    Для выявления маркеров глиобластомы мы сравнили экспрессию генов в глиобластоме и нормальном головном мозге, используя вэб-сайт SAGE Genie, и сравнили полученные результаты с опубликованными данными. Девять SAGE-библиотек ...
  • Evolutionary karyotypic theory of cancer versus conventional cancer gene mutation theory 
    Stepanenko, A.A.; Kavsan, V.M. (Вiopolymers and Cell, 2012)
    Согласно общепризнанной генной теории рака, в течение последних десятилетий рак считали генным заболеванием, возникающим в результате детерминистического последовательного накопления мутаций в небольшой группе раковых ...
  • Expression of genes belonging to the IGF-system in glial tumors 
    Dmitrenko, V.V.; Kavsan, V.M.; Boyko, O.I.; Rymar, V.I.; Stepanenko, A.A.; Balynska, O.V.; Malisheva, T.A.; Rozumenko, V.D.; Zozulya, Y.P. (Цитология и генетика, 2011)
    The discrepancies arising from conflicting evidence on the results obtained by different laboratories in human gliomas are discussed. Our data highlight the importance of viewing the IGF-related proteins as a complex ...
  • From reverse transcription to human brain tumors 
    Dmitrenko, V.V.; Avdieiev, S.S.; Areshkov, P.O.; Balynska, O.V.; Bukreieva, T.V.; Stepanenko, A.A.; Chausovskii, T.I.; Kavsan, V.M. (Вiopolymers and Cell, 2013)
    Reverse transcriptase from avian myeloblastosis virus (AMV) was the subject of the study, from which the investigations of the Department of biosynthesis of nucleic acids were started. Production of AMV in grams quantities ...
  • Growth suppression activity of bradykinin antagonists in glioma cells 
    Avdieiev, S.S.; Gera, L.; Hodges, R.; Vassetzky, Y.S.; Kavsan, V.M. (Вiopolymers and Cell, 2014)
    The present study was Aimed at analyzing the effect of bradykinin (BK) antagonists on proliferation of the human glioblastoma cells U373. Methods. MTT-based cell proliferation assay. Results. BKM-570 revealed a significant ...
  • Immortalization and malignant transformation of eucaryotic cells 
    Stepanenko, O.A.; Kavsan, V.M. (Цитология и генетика, 2012)
    This review is aimed at understanding the mechanisms of cell immortalization by different «immortalizing agents», oncogene-induced cell transformation of immortalized cells and moderate response of the advanced tumors to ...
  • Multisubunit complex eEF1H in human glial tumors: from mRNA to protein 
    Veremieva, M.V.; Malysheva, T.A.; Zozulya, Y.P.; Rozumenko, V.D.; Sidorik, L.L.; Kavsan, V.M.; Negrutskii, B.S.; El'skaya, A.V. (Вiopolymers and Cell, 2010)
    Aim. To investigate protein level of all subunits of the eukaryotic elongation translation factor eEF1H (eEF1A, eEF1Bα, eEF1Bβ and eEF1Bγ) in glial tumors of human brain in comparison with normal brain. Methods. The eEF1H ...
  • Stimulation of transient versus sustained ERK1/2 phosphorylation by relative chitinase-like proteins CHI3L1 and CHI3L2 correlates with different kinase localization and biological outcome 
    Areshkov, P.O.; Avdieiev, S.S.; Iershov, A.V.; Kavsan, V.M. (Вiopolymers and Cell, 2011)
    Aim. To determine 293 and U373 cell response and ERK1/2 activation profile after CHI3L1 or CHI3L2 treatment. Methods. Specific activation and localization of ERK1/2 kinases after CHI3L1 or CHI3L2 addition to unsupplemented ...
  • Structure and function of oncogene-transfected immortal cells 
    Kavsan, V.M.; Kulagova, T.A.; Kuznetsova, T.A.; Semenkova, G.N.; Stepanenko, A.A.; Vassetzky, Y.S. (Вiopolymers and Cell, 2014)
    Previously we have characterized a new oncogene CHI3L1, overexpressed in the glioblastoma and the malignant 293_CHI3L1 cells, stably producing the CHI3L1 angiogenic oncoprotein. The 293_CHI3L1 cells proliferated faster and ...